Reductive amination (also known as reductive alkylation) is a form of amination that converts a carbonyl group to an amine via an intermediate imine. The carbonyl group is most commonly a ketone or an aldehyde.

2017年9月1日 · One alternative that works extremely well is to form the imine of an amine with an appropriate aldehyde or ketone, and then to reduce the imine to an amine. This is called reductive amination and avoids the problem of multiple alkylations.

A biomimetic direct reductive amination of ketones relies on selective imine activation by hydrogen bond formation with thiourea as hydrogen bond donor and utilizes the Hantzsch ester for transfer hydrogenation. The method allows the …

2023年1月23日 · Aldehydes and ketones can be converted into 1°, 2° and 3° amines using reductive amination. The reaction takes place in two parts. The first step is the nucleophiic addition of the carbonyl group to form an imine. The second step is the reduction of the imine to an amine using an reducing agent.

Table 2 Optimization of reductive amination. under Ar and stirred in dry THF for 3 h. Then THF was evaporated under reduced pressure and the corresponding reducing agent NaBH4, NaBH(OAc)3 or NaBH3CN was added with the same solvent as in unified procedure for that.

2023年9月5日 · Reductive amination is the process of conversion of a carbonyl group to an amine through an imine ion intermediate. It is a chemical reaction that converts aldehyde and ketones into 1°, 2° and 3° amine .

Reductive amination is a fundamental and versatile chemical transformation essential in organic chemistry. This transformative process involves the conversion of carbonyl compounds, such as aldehydes and ketones, into primary and secondary amines by employing a reducing agent, typically in the presence of a catalyst.

2020年8月27日 · Aldehydes and ketones can be converted into 1 o, 2 o and 3 o amines using reductive amination. The reaction takes place in two parts. The first step is the nucleophiic addition of the carbonyl group to form an imine. The second step is the reduction of the imine to an amine using an reducing agent.

Reductive amination is a powerful and reliable strategy for the formation of C–N bonds, and can avoid the problem of overalkylation that often accompanies direct alkylation of amines with alkyl halides.

Reductive Amination. Aldehydes and ketones can be converted into 1 o, 2 o and 3 o amines using reductive amination. The reaction takes place in two parts. The first step is the nucleophiic addition of the carbonyl group to form an imine. The second step is the reduction of the imine to an amine using an reducing agent.