Refractory AML: Most patients achieve a remission (an absence of signs and symptoms) after initial treatment for acute myeloid leukemia (AML). However, some patients have residual leukemic cells in their marrow even after intensive treatment.

2024年1月4日 · Most patients with acute myeloid leukemia (AML) develop refractory/relapsed (R/R) disease even in the presence of novel and targeted therapies. Given the biological complexity of the disease and differences in frontline treatments, there are therapies approved for only subgroups of R/R AML, and enrollment in clinical trials should be first ...

2020年8月27日 · Treatment of relapsed or refractory acute myeloid leukemia (AML) has presented challenges for hematologists for decades. Despite numerous clinical studies, outcomes are consistently disappointing with 5-year overall survival rates of ∼10%. Allogeneic hematopoietic cell transplantation at the time of second complete remission remains the only …

INTRODUCTION The first step in the successful treatment of a patient with acute myeloid leukemia (AML) is the attainment of a complete remission (CR), which is characterized by (table 1): Normal values for absolute neutrophil count (>1000/microL) and platelet count (>100,000/microL), and independence from red cell transfusion. A bone marrow biopsy that …

2015年7月16日 · Primary refractory acute myeloid leukemia (AML) and early relapse remain among the most challenging scenarios in the management of AML. Primary refractory or resistant disease as defined by not achieving complete remission (CR) (ie, a remaining blast count of 5% or more after 1 to 2 cycles of intense induction therapy 1 ) occurs in 10% to 40% of the patient …

Primary refractory acute myeloid leukemia (AML), or primary induction failure, represents a continued challenge in clinical management. This review presents an overview of primary refractory disease and a discussion of risk factors for induction ...

2023年6月28日 · Relapsed AML refers to leukemia that has returned after receiving treatment and reaching remission, and refractory AML means it did not respond to treatment. Learn more.

2024年1月22日 · Refractory Acute Myeloid Leukemia (AML) presents a formidable challenge due to its resistance to conventional treatments.

2024年8月22日 · Learn the difference between relapsed and refractory AML, as well as how a diagnosis of either may affect your treatment options and outlook.

2021年1月27日 · Refractory acute myeloid leukemia (AML) is a very challenging complication in the management of AML. In this condition, the disease is refractory or resistant and patients fail to achieve complete ...