Retinoblastoma - Wikipedia
Almost half of children with retinoblastoma have a hereditary genetic defect associated with it. In other cases, retinoblastoma is caused by a congenital mutation in the chromosome 13 gene …
Retinoblastoma - GeneReviews® - NCBI Bookshelf
2000年7月18日 · Retinoblastoma is a malignant tumor of the developing retina that occurs in children, usually before age five years. Retinoblastoma may be unifocal or multifocal.
Retinoblastoma: MedlinePlus Genetics
Retinoblastoma is a rare type of eye cancer that usually develops in early childhood, typically before the age of 5. Explore symptoms, inheritance, genetics of this condition.
Retinoblastoma - StatPearls - NCBI Bookshelf
2023年8月8日 · Retinoblastoma occurs as a result of a mutation in the RB1 tumor suppressor gene located at the long arm of chromosome 13 at locus 14 (13q14). Formation of tumor …
What Causes Retinoblastoma? | Causes of Eye Cancer in Children
2021年12月3日 · The most important gene in retinoblastoma is the RB1 tumor suppressor gene. This gene makes a protein (pRb) that helps stop cells from growing too quickly. Each cell …
Understanding retinoblastoma: epidemiology and genetics - PMC
Retinoblastoma originates in a photoreceptor cell of the retina and is associated with a mutation in the RB1 gene (which is normally responsible for tumour suppression). Each person inherits …
Retinoblastoma - Genes and Disease - NCBI Bookshelf
Retinoblastoma occurs in early childhood and affects about 1 child in 20,000. The tumor develops from the immature retina - the part of the eye responsible for detecting light and color. There …
Retinoblastoma - National Eye Institute
2024年12月4日 · Retinoblastoma happens when changes in a gene cause retina cells to grow into a tumor. Most of the time, these gene changes happen by chance — but sometimes the …
Retinoblastoma - Symptoms and causes - Mayo Clinic
2024年3月8日 · Retinoblastoma is caused by changes inside the cells in the eye. It's not always clear what causes the changes that lead to this eye cancer. Retinoblastoma starts when cells …
Genetics of Retinoblastoma - PubMed
Retinoblastoma is a malignant retinal tumor that affects young children. Mutations in the RB1 gene cause retinoblastoma. Mutations in both RB1 alleles within the precursor retinal cell are …