2024年12月1日 · Pharmacological inhibition of ferroptosis and autophagy reduces the heightened apoptosis caused by artesunate. Additionally, artesunate suppresses STAT3 activation, and genetic knockdown of STAT3 enhances artesunate-induced autophagy and ferroptosis while upregulating proteins related to cell cycle and apoptosis (Chen et al., 2021).

2023年9月1日 · In particular, NCOA4 promotes ferritin phagocytosis, RAB7A-dependent lipophagy, BECN1-mediated system Xc-inhibition, STAT3-induced lysosomal membrane permeability change, and HSP90-related partner-mediated autophagy can all promote ferroptosis. Autophagy-dependent ferroptosis may contribute to the treatment of …

Accumulating studies have revealed crosstalk between autophagy and ferroptosis at the molecular level. In this review, we summarize the mechanisms of ferroptosis and autophagy, and more importantly, their roles in the drug resistance of cancer.

In this review, we summarize the processes of autophagy and ferroptosis and discuss their crosstalk mechanisms at the molecular level. The original study shows that ferroptosis is morphologically, biochemically, and genetically distinct from autophagy and …

2022年6月1日 · Genetic and pharmacological inhibition of STAT3 triggers ferroptosis by transcriptionlly regulation of GPX4, SLC7A11, and FTH1 in gastric cancer. A potent and selective STAT3 inhibitor W1131, with strong anti-tumor effects, is developed. Ferroptosis plays a key role in the progression and chemoresistance of gastric cancer.

2023年3月21日 · Ferroptosis is a form of iron-dependent regulated cell death and has two major hallmarks, intracellular iron overload and redox system disorder. The activation of inflammatory signaling...

2025年1月6日 · Ferroptosis and autophagy are two main forms of regulated cell death (RCD). Ferroptosis is a newly identified RCD driven by iron accumulation and lipid peroxidation. Autophagy is a self-degradation system through membrane rearrangement.

Recent studies suggest that the level of autophagy in a cell can impact its sensitivity to ferroptosis. The selective destruction of certain proteins or organelles through autophagy can trigger ferroptosis by promoting iron accumulation and lipid peroxidation.

2018年9月10日 · Here, we demonstrate that STAT3 is a positive regulator of ferroptosis in human pancreatic ductal adenocarcinoma (PDAC) cell lines. Activation of the MAPK/ERK pathway, but not inhibition of system Xc -, was required for STAT3 activation during erastin-induced ferroptosis.

In particular, NCOA4-facilitated ferritinophagy, RAB7A-dependent lipophagy, BECN1-mediated system x c-inhibition, STAT3-induced lysosomal membrane permeabilization, and HSP90-associated chaperone-mediated autophagy can promote ferroptosis. In this review, we summarize current knowledge on the signaling pathways involved in ferroptosis, while ...