Intestinal stem cell dynamics in homeostasis and cancer
2022年2月10日 · The stem cell niche dictates intestinal stem cell (ISC) functionality during homeostasis and repair and greatly influences cancer initiation. Mutant stem cells can act as supercompetitors and modulate the local microenvironment in driving tumor initiation and …
The Role of Cancer Stem Cells in Colorectal Cancer: From the …
Cancer stem cells (CSCs) fuel tumor growth, metastasis and resistance to therapy in colorectal cancer (CRC). These cells therefore represent a promising target for the treatment of CRC but are difficult to study because of the complexity of their ...
Intestinal stem cells and the colorectal cancer microenvironment
2014年2月2日 · Core tip: Colorectal (CRC) cancer stem cells are a theorized but poorly characterized cell population believed to be crucial for tumor growth, spread, and tenacity. CRC stem cells share many similar characteristics of normal intestinal stem cells and are hypothesized to originate directly from them.
Colorectal Cancer Stem Cells: An Overview of Evolving Methods …
According to the stem cell model, most tumors, including colorectal cancer (CRC), contain a small population of cancer stem cells (CSCs) that are deeply implicated in tumor generation and progression, drug resistance, recurrence, and metastasis [1, 2].
The Intestinal Stem Cell Signature Identifies Colorectal Cancer Stem ...
2011年5月6日 · EphB2 sorted ISC-like tumor cells display robust tumor-initiating capacity in immunodeficient mice as well as long-term self-renewal potential. Taken together, our data suggest that the ISC program defines a cancer stem cell niche within colorectal tumors and plays a central role in CRC relapse.
Pathways regulating intestinal stem cells and potential …
2024年10月10日 · Intestinal stem cells (ISCs) regulation is intricately orchestrated by diverse signaling pathways, among which are the WNT, BMP, NOTCH, EGF, Hippo, Hedgehog and NF-κB, each contributing to the complex control of these cells' behavior.
FXR Regulates Intestinal Cancer Stem Cell Proliferation
2019年2月21日 · Here, we show that the convergence of dietary factors (high-fat diet) and dysregulated WNT signaling (APC mutation) alters BA profiles to drive malignant transformations in Lgr5-expressing (Lgr5 +) cancer stem cells and promote an adenoma-to …
Stem cells in homeostasis and cancer of the gut - PMC
2019年3月30日 · In this review we present an overview of the current knowledge on ISCs in homeostasis and their role in malignant transformation. Also, we discuss the existence of stem cells in intestinal adenomas and CRC and how these cells contribute to (pre-)malignant growth.
Portrait of Cancer Stem Cells on Colorectal Cancer: Molecular ...
2021年2月5日 · Increasing evidence suggests that the heterogeneous nature of CRC is related to colorectal cancer stem cells (CCSCs), a small cells population with stemness behaviors and responsible for tumor progression, recurrence, and therapy resistance.
Stem cell retrograde: A new reason why colorectal cancer ... - Cell …
2023年3月13日 · Stem cell retrograde provides important insights into the higher colorectal cancer incidences relative to small bowel cancer. This implies that the stronger retrograde behaviors of SI stem cells reduce gene mismatch probabilities and decrease the frequency of stem cell abnormal divisions during self-replication.