Fluorescein is a fluorophore commonly used in microscopy, in a type of dye laser as the gain medium, in forensics and serology to detect latent blood stains, and in dye tracing. Fluorescein has an absorption maximum at 494 nm and emission maximum of 512 nm (in water).

Approximately 80% of fluorescein dye is attached to plasma proteins, principally albumin, after injection into the circulation. The dye is metabolized by both the liver and the kidneys and is excreted in the urine within 24 to 36 hours. Fluorescein Sodium is the most common commercially used salt of Fluorescein.

FLUORESCEIN SODIUM is a small molecule drug with a maximum clinical trial phase of IV (across all indications) that was first approved in 1976 and has 5 investigational indications. A phthalic indicator dye that appears yellow-green in normal tear film and bright green in a more alkaline medium such as the aqueous humor.

Fluorescein sodium is a sodium salt and an organic fluorescent dye with peak excitation at 494 nm and peak emission at 512 nm. It has been safely used in humans for many years, predominantly in ophthalmology for retinal angiography, and the cost of fluorescein sodium is relatively low when compared with the cost of other agents such as 5-ALA [47] .

Sodium fluorescein is used as a fluorescent tracer to study blood-brain barrier (BBB) and blood-spinal cord barrier (BSCB) permeability in rodent models. The dye was used as a probe substrate in the study of organic anion transporting polypeptide (OATP) mediated drug transport in …

Sodium fluorescein (NaFl) is a fluorescent dye with a molecular weight of 376.3 g/mol that accumulates in tumor tissue where blood brain barrier (BBB) breakdown occurs and thus, enhances tumor visualization, contributing to the extent of resection which is in turn associated with a better overall survival rate (5–9).

Mar 25, 2013 · Fluorescein is an organic dye also known as D & C Yellow No. 7 and many other names. A. von Baeyer first synthesized it in 1871 from phthalic anhydride and resorcinol and called it resorcinphthalein. It is not soluble in water or many organic solvents, but its disodium salt (fluorescein sodium, uranine, D & C Yellow No. 8) is highly water-soluble.

Feb 20, 2015 · Other properties listed for this fluorescent dye include the physical form, solubility, melting point, boiling point, pKa, absorption maxima, emission maxima, molar extinction coefficient and quantum yield. The chapter also includes references on the use, properties, and safety/toxicity of fluorescein on humans, animals and the environment.

Fluorescein solution is especially useful for examining the tear drainage system, but much more dye is applied than with the paper strip. If the fluorescein solution becomes contaminated, pathogenic bacteria such as Pseudomonas spp. may grow in it. 17-19 Thus it is customary to use commercially available mini-packages. Michel Eid Farah MD, ...

Fluorescein Sodium is a water-soluble dye that appears orange and emits a green fluorescence when exposed to short-wavelength light. It is used in the visualization of ocular surface staining, with optimal visibility achieved within 1-2 minutes after application.