In cell biology, the spindle apparatus is the cytoskeletal structure of eukaryotic cells that forms during cell division to separate sister chromatids between daughter cells.

5 天之前 · The spindle apparatus is crucial in cell division. It ensures chromosomes are evenly distributed. Understanding the spindle apparatus helps us grasp how cells duplicate accurately. This structure, composed of microtubules, plays a vital role during mitosis and meiosis. Without it, cells could not divide properly, leading to genetic issues.

2023年7月22日 · This pattern has a “spider web” appearance extending from the centriole to the centromeres. The pattern is suggestive of autoantibodies to the microtubules and its significance is unclear; however, an association between the spindle fiber pattern and carpal tunnel syndrome has been suggested.

2006年5月11日 · Through the spindle apparatus, the daughter chromosomes move to the poles at opposite ends of the cell. The daughter chromosomes migrate centromeres first and the kinetochore fibers become shorter as the chromosomes near a pole.

2021年2月26日 · Any of a network of filaments that collectively form a mitotic spindle (in mitosis) and meiotic spindle (in meiosis). It is chiefly involved in moving and segregating the chromosome s during nuclear division.

The spindle apparatus in meiotic cells is responsible for separating homologous chromosomes during meiosis I and sister chromatids during meiosis II to produce haploid oocytes (11, 30). Spindle disruption perturbs chromosome segregation and contributes to …

2023年2月17日 · What are spindle fibers in biology & what are they made of. When do mitotic spindle apparatus form with their location, formation & role in mitosis with diagram

Spindle apparatus is a complex bipolar structure consisting of antiparallel array of dynamic microtubules (MTs) that capture kinetochores assembled on the duplicated and condensed chromosomes to drive chromosomes segregation equally into daughter cells [11,12].

The spindle apparatus is a structure of the eukaryotic cytoskeleton involved in mitosis and meiosis, often referred to as the mitotic spindle during mitosis and the meiotic spindle during meiosis. Its function is to segregate chromosomes during cell division (either mitosis or meiosis) to the daughter cells .

The mitotic spindle is the macromolecular machine that segregates chromosomes to two daughter cells during mitosis. The major structural elements of the spindle are microtubule polymers, whose intrinsic polarity and dynamic properties are critical for bipolar spindle organization and function.