Thrombin–antithrombin complex (TAT) is a protein complex of thrombin and antithrombin. [1][2] It is a marker of net activation of coagulation. [3] TAT is formed in response to the high thrombin level caused by coagulation following a ruptured vessel.

Thrombin-antithrombin complexes (TAT) form covalently following thrombin generation and have a plasma half-life of 10 to 15 minutes. The presence of TAT indicates ongoing thrombin formation and the consumption of antithrombin.

Thrombin-antithrombin complexes reflect the amount of thrombin that is neutralized by antithrombin and serves as a surrogate marker for thrombin generation. On the other hand, total thrombus generation is calculated from the first derivative of the thromboelastographic waveform.

2023年11月2日 · Therefore, our objective was to evaluate the diagnostic potential of selected hemostatic biomarkers (thrombin-antithrombin complex (TAT), soluble thrombomodulin (sTM), tissue plasminogen activator inhibitor complex (tPAI-C), α 2-plasmin inhibitor plasmin complex (PIC) and anti-thrombin III (ATIII)) in assessing DIC before reaching its ...

Thrombin is inhibited by antithrombin, forming a thrombin-antithrombin (TAT) complex. Therefore, the TAT complex also reflects the functional state of the coagulation system. This complex is influenced to a smaller degree by pre-analytical factors such as the technique of blood sampling.

Thrombin generation was determined by the calibrated automated thrombogram using platelet-poor-plasma reagent containing 1 pM tissue factor and 4 μM phospholipids. TAT and F1+2 were measured using commercial enzyme-linked immunosorbent assays.

Thrombin Antithrombin Complex is a stable covalent structure formed by the binding of thrombin and antithrombin. It plays a crucial role in inhibiting clotting enzymes, particularly thrombin and factor Xa, contributing to the anticoagulant effects of heparin.

In the absence of heparin, Antithrombin inhibits thrombin in a progressive manner by 1:1 stoichiometric complex by second-order kinetics and forms a complex with thrombin most likely by the arginine reactive site located on Antithrombin (Rosenberg and Damus, 1973) (Fig. 13.1). To a lesser degree, Factors IXa, Xa, XIa, and XIIa are also inhibited.

Thrombin‐antithrombin complex is a molecular complex composed of thrombin and AT, a primary thrombin inhibitor, in a 1:1 ratio. Increased TAT indicates excess thrombin production and serve as a marker reflecting prothrombotic status.

Thrombin-antithrombin complex (TAT) is a complex composed of thrombin and its inhibitor in equal proportion, which is mainly used as a marker for initiating the blood coagulation system. The plasmin-α2-plasmin inhibitor complex (PIC) is a marker for initiating the fibrinolytic system.