2011年7月24日 · Now the structure of mitochondrial uncoupling protein 2 (UCP2), a member of the carrier family that translocates protons across the mitochondrial inner membrane, has been...

In contrast to UCP1 and UCP3, which are primarily expressed in adipose and smooth muscle, UCP2 is expressed on many different tissues [6] including the kidney, liver, GI tract, brain, and skeletal muscle.

2024年12月25日 · UCP2 (Uncoupling Protein 2) is a Protein Coding gene. Diseases associated with UCP2 include Body Mass Index Quantitative Trait Locus 4 and Hyperinsulinism Due To Ucp2 Deficiency. Among its related pathways are Mitochondrial Uncoupling and Respiratory electron transport. An important paralog of this gene is UCP3.

Mitochondrial uncoupling protein 2 (UCP2) is an integral membrane protein in the mitochondrial anion carrier protein family, the members of which facilitate the transport of small molecules across the mitochondrial inner membrane.

In this review, we describe novel findings concerning events that can occur in a concerted manner at various levels: Ucp2 gene mutation (single nucleotide polymorphisms), UCP2 mRNA and protein expression (transcriptional, translational, and protein turn-over regulation), UCP2 proton conductance (ligands and post-transcriptional modifications ...

In this summary the pathway/subsystems to which the gene belongs is shown together with the associated cellular compartment for the reactions based on metabolite information. The number of proteins and metabolites in the pathway is shown as well as …

2022年7月1日 · The absence of human UCP2 structure, lack of understanding of Cl − ion transport mechanism in the UCP2 and the associated biological functions motivated us to model the protein and investigate its structural and dynamical properties in a realistic mitochondrial lipid membrane system.

2014年9月2日 · Using NMR and functional mutagenesis, Berardi and Chou elucidate how the uncoupling protein UCP2 uses free fatty acids (FAs) to dissipate the proton gradient in mitochondria by acting as a FA flippase. GDP directly binds inside the UCP2 cavity and blocks fatty acid recognition, which inhibits UCP2 activation.

Uncoupling protein 2 (UCP2) is an integral membrane protein that belongs to the family of mitochondrial anion carrier proteins. The absence of human UCP2 structure, lack of understanding of Cl - ion transport mechanism in the UCP2 and the associated biological functions motivated us to model the protein and investigate its structural and ...

2021年1月26日 · The simulated structures include (a) the published NMR structure of mUCP2 (PDB code 2LCK, organism Mus musculus) determined by NMR molecular fragment replacement, (b) the homology modeled structure of the primary sequence of UCP2 protein to crystallographic structure of ANT protein (PDB code 1OKC, 2.2 Å, high resolution, organism Bos taurus ...