In this study, we aimed to review the mechanism of development of atherosclerosis, including endothelial dysfunction, fatty streak formation, fibrous plaque formation, and plaque rupture.

Atherosclerosis, the principal cause of heart attack, stroke, and peripheral vascular disease, remains a major contributor to morbidity and mortality in the Western World. Disease progression is slow, beginning in childhood and usually becoming clinically manifest in middle age or later.

1995年5月1日 · On the contrary, atherosclerosis seems to be a chronic inflammatory condition that is converted to an acute clinical event by the induction of plaque rupture, which in turn leads to thrombosis. 1 What are the basic mechanisms that induce this sequence of events?

2020年9月10日 · Atherosclerosis is a chronic inflammatory disease in which there is a build up of plaques inside arteries. These plaques are principally composed of lipids that induce an inflammatory reaction causing turbulent flow with atherosclerotic cardiovascular disease (ASCVD) as …

2014年6月6日 · In this review, we discuss mechanisms of atherosclerotic plaque initiation and progression; how plaques suddenly precipitate life-threatening thrombi; and the concepts of plaque burden, activity, and vulnerability.

In this article we present the current knowledge about the mechanism of formation of atherosclerotic lesions and we summarize available data on in vivo studies, which investigated whether oxysterols have properties to cause the formation …

Numerous studies have elucidated molecular mechanisms of inflammation in atherosclerosis, and it is widely accepted that both innate and adaptive immune responses play key roles for initiation and progression of atherosclerosis, leading to clinical manifestations of CVDs.

2021年9月14日 · Atherosclerosis is characterized by low-grade, chronic inflammation, and the balance between pro-inflammatory and inflammation-resolving mechanisms dictates the clinical outcomes.

High levels of UA promote atherosclerosis by impairing autophagy through NRF2-mediated dysfunction and inducing ferroptosis, providing insights into the molecular mechanisms underlying the pro-atherogenic effects of UA.

2022年3月20日 · Atherosclerosis is initiated by endothelium activation and, followed by a cascade of events (accumulation of lipids, fibrous elements, and calcification), triggers the vessel narrowing and activation of inflammatory pathways.