Taper GC dose as guided by underlying condition until 30 mg/m 2 /day of hydrocortisone equivalent is reached (if taper not required for underlying condition, reduce to 30 mg/m 2 /day) 2. Then taper by 10-20% every 3–7 days until patient is on physiological GC dose (8–10 mg/m 2 /day hydrocortisone equivalent)

Randomized controlled trials, case-control studies, and prospective observational studies comparing at least 2 tapering strategies of medium- to high-dose (>7.5 mg but ≤100 mg oral prednisone equivalent daily), extended-duration (≥10 days) corticosteroids were included if they reported at least 1 efficacy and 1 adverse effect parameter.

Despite its efficacy, steroid-induced side effects generally require tapering of the drug as soon as the disease being treated is under control. Tapering must be done carefully to avoid both recurrent activity of the underlying disease and possible cortisol deficiency resulting from hypothalamic-pituitary-adrenal axis (HPA) suppression during ...

Corticosteroids have long been used to effectively treat rheumatic disorders, but adverse effects associated with extended-duration regimens generate disagreement among clinicians regarding optimal tapering strategies.

Two studies (Bazi 2021 1 and Zecca 2021 9) compared 3 and 5 day courses of treatment for MS relapses with intravenous methylprednisolone (IV-MP) and compared a tapering regime with prednisone versus an abrupt stop.

The process of tapering glucocorticoids in patients whose lives and daily function are greatly affected by their rheumatoid arthritis is a highly personal experience that might not be reducible to one single algorithm.

Properly conducted GC withdrawal is crucial in preventing GC-induced AI; however, adrenal suppression may occur despite following recommended GC tapering regimens. A suspicion of GC-induced AI requires careful diagnostic workup and prompt introduction of …

2022年1月1日 · We present exemplary tapering schemes for rheumatoid arthritis, systemic lupus erythematosus, and giant cell arteritis, derived from randomized trials and guidelines. Glucocorticoids (GCs) remain regularly used drugs in patients with chronic inflammatory rheumatic diseases.

2022年1月1日 · We present exemplary tapering schemes for rheumatoid arthritis, systemic lupus erythematosus, and giant cell arteritis, derived from randomized trials and guidelines. Glucocorticoids (GCs) remain regularly used drugs in patients with chronic inflammatory rheumatic diseases.

2021年4月1日 · Objective: To compare the efficacy of the standard slow-tapering regimen of prednisone therapy with a rapid-tapering regimen. Design: From June 1, 2009, to July 31, 2013, a multicenter, parallel, single-blind randomized trial was conducted to compare 2 regimens of prednisone tapering.