Mechanisms of human embryo development: from cell fate to tissue shape ...
Recent evidence indicates that the crosstalk between cell fate and tissue shape plays an important role during key human developmental events, including compaction and polarisation in pre-implantation embryos, embryonic epithelialisation at the time of implantation and germ lineage commitment at gastrulation.
Embryo mechanics cartography: inference of 3D force atlases
2023年12月6日 · We first focused on the shape of the embryo from 16 cells to the early gastrula, where divisions are reported to be asynchronous with cell divisions that alternate between the animal and...
Mapping morphogenesis and mechanics in embryo models - Nature
2023年12月6日 · Recent methodological advances in measurements of geometry and forces in the early embryo and its models are enabling a deeper understanding of the complex interplay of genetics, mechanics and...
Integrating Cellular Dimensions with Cell Differentiation During …
In this review, we summarize recent advances that elucidate the contribution of the physical dimensions of a cell to major embryonic transitions and cell fate specification in vivo. We also highlight techniques and newly evolving methods for manipulating the sizes and shapes of cells and whole embryos in situ and ex vivo.
Mechanisms of human embryo development: from cell fate to tissue shape ...
2020年7月17日 · Dissecting the basic mechanisms that coordinate cell fate and tissue shape will generate an integrated understanding of early embryogenesis and new strategies for therapeutic intervention in early pregnancy loss.
Day 3 embryo shape as a morphologic selection parameter in in …
2012年8月14日 · Embryo shape was evaluated in tertiles, where the most round embryos were considered the referent group against which less-round embryos were evaluated. To our knowledge, this is the first and only study assessing the shape of embryos on day 3 as a morphologic predictor of implantation.
Sensing how an embryo takes shape - Nature
2024年7月29日 · An article in Nature Materials describes the bioprinting of hydrogel force sensors directly into the tissues of live embryos to quantify the mechanical forces driving morphogenesis.
Embryonic Patterning: To BMP or Not to BMP, That Is the …
1997年4月18日 · In vertebrates, the three embryonic germ layers—ectoderm, mesoderm, and endoderm—are patterned. This review focuses on the dorsal–ventral patterning of the ectoderm and the mesoderm. The ectoderm produces the epidermis or skin as a ventral derivative and the nervous system as a dorsal derivative (Figure 1).
A first look at the earliest decisions that shape a human embryo
2018年5月23日 · Researchers have discovered a new type of stem cell that resembles cells in the early human embryo during the transition of 'genomic power' from mother to embryo.
Early human development and stem cell-based human embryo …
2024年10月3日 · We present the stem cell types and stem cell-based embryo models, their advantages and limitations, and highlight efforts to overcome bottlenecks. Human embryonic development starts with the formation of the zygote, which undergoes cleavage divisions to form the embryo and extra-embryonic tissues.