GLUT3 facilitates the transport of glucose across the plasma membranes of mammalian cells. GLUT3 is most known for its specific expression in neurons and has originally been designated as the neuronal GLUT .

2015年7月16日 · （左图)人源葡萄糖转运蛋白glut3处于不同状态的3个晶体结构。 (右图）迄今已获得的葡萄糖转运蛋白gluts的晶体结构以及在此基础上进一步完善的gluts工作模型。

2015年颜宁团队再次利用晶体技术解析出glut3处于不同构象的3个高分辨率晶体结构，不同于glut1的向内开放构象，此次解析出的glut3分别处于向胞外开放和向胞外闭合两种状态，因此这一研究将glut家族蛋白通过交替开放转运底物的整个过程基本展示了出来，清晰的 ...

2022年10月12日 · We found that the glucose transporter GLUT3 is essential for the effector functions of Th17 cells in models of autoimmune colitis and encephalomyelitis. At the molecular level, we show that GLUT3-dependent glucose uptake controls a metabolic-transcriptional circuit that regulates the pathogenicity of Th17 cells.

The overriding question that drove the early work in GLUT3 in the brain was: why would neurons need a separate glucose transporter isoform; what is it about GLUT3 that specifically suits the needs of the highly metabolic and oxidative neuron with its high glucose demand?

GLUT3 protein is located mainly in the brain where it is responsible for glucose uptake into neurons, and GLUT4 is the major glucose transporter in adipocytes and skeletal and cardiac muscle. GLUT5 is not a glucose transporter; instead it is a fructose transporter expressed in the brush border membrane of enterocytes.

葡萄糖转运体 (GLUT)是一类调控细胞外葡萄糖进入细胞内的跨膜蛋白家族，参与糖代谢，炎性反应和免疫应答等过程。

2015年7月15日 · GLUT3 is known as the 'neuronal glucose transporter' for its primary function in neurons, but it is also required for glucose uptake in sperm, pre-implantation embryos, and circulating...

GLUT3 stabilizes neuronal glucose uptake and utilization, influences brain development and function, and ameliorates aging-related manifestations. Neuronal GLUT3 is regulated by synaptic activity, hormones, nutrition, insulin and insulin-like growth factor 1 in physiological conditions, and is also upregulated by hypoxia-ischemia.

glut3 以高亲和力和强大的运输能力摄取葡萄糖，对神经元能量代谢很重要。本综述总结了神经元 glut3 在生理条件下和疾病中脑代谢、功能和发育中的作用，旨在提供对神经元葡萄糖代谢及其对大脑影响的见解。