2016年3月3日 · LUJV GPC is cleaved by site 1 protease (S1P) at the RKLM motif, and treatment with the S1P inhibitor PF-429242 reduced LUJV production. The family Arenaviridae is divided into Old World (OW) and New World (NW) arenaviruses on the basis of the results of geographical, serological, and phylogenetic analyses.

Lujo virus (LUJV), a new member of the family Arenaviridae and the first hemorrhagic fever-associated arenavirus from the Old World discovered in three decades, was isolated in South Africa during an outbreak of human disease characterized by nosocomial transmission and an unprecedented high case fa …

2024年8月21日 · Lujo virus (LUJV) is a human pathogen that was the cause of a deadly hemorrhagic fever outbreak in Africa. LUJV is a divergent member of the Arenaviridae with some similarities to both the...

2018年8月27日 · To uncover the structure of the receptor-binding module of LUJV, to reveal how LUJV recognizes NRP2, and to elucidate the structural differences between LUJV and the Old World and New...

Lujo virus (LUJV) is a human pathogen that was the cause of a deadly hemor-rhagic fever outbreak in Africa. LUJV is a divergent member of the Arenaviridae with some similarities to both the...

Lujo virus (LUJV) has emerged as a highly fatal human pathogen. Despite its membership among the Arenaviridae, LUJV does not classify with the known Old and New World groups of that viral family. Likewise, LUJV was recently found to use neuropilin-2 (NRP2) as a cellular receptor instead of the canon …

2024年8月21日 · Lujo virus (LUJV) is a human pathogen that was the cause of a deadly hemorrhagic fever outbreak in Africa. LUJV is a divergent member of the Arenaviridae with some similarities to both the "Old World" and "New World" serogroups, but it uses a cell-entry receptor, neuropilin-2 (NRP2), that is distinc …

2018年9月6日 · Genomic data indicated that LUJV could not be classified into the two canonical ‘Old World’ and ‘New World’ groups of arenaviruses. Almost a decade later, the main cellular receptor for LUJV GP1, Neuropilin-2 (NRP2), was identified in a …

卢霍病毒（LUJV）已成为一种致命的人类病原体。 尽管LUJV隶属于Arenaviridae，但并未与该病毒家族的已知旧世界和新世界集团进行分类。 同样，最近发现LUJV使用Neuropilin-2（NRP2）作为细胞受体，而不是旧世界和新世界舞台病毒使用的规范受体。

2014年2月24日 · Several studies have revealed αDG and TfR1 to be major cellular receptors for pathogenic Old World and New World clade B arenaviruses, respectively. In the present study, we demonstrated that LUJpv cell entry occurred independently of both αDG and TfR1.