Melanoma is a type of skin cancer that develops when melanocytes (the cells that give the skin its tan or brown color) start to grow out of control. Melanoma is much less common than some other types of skin cancers. But melanoma is more dangerous because it’s much more likely to spread to other parts of the body if not found and treated early.

2023年12月30日 · Melanoma happens when something changes healthy melanocytes into cancer cells. Melanocytes are skin cells that make pigment that gives skin its color. The pigment is called melanin.

2023年4月24日 · This Review outlines how the developmental pathways that are involved in melanocyte development and skin pigmentation are highjacked by melanoma cells to drive melanomagenesis, progression and...

Melanoma is the most dangerous type of skin cancer; it develops from the melanin-producing cells known as melanocytes. [1] It typically occurs in the skin, but may rarely occur in the mouth, intestines, or eye (uveal melanoma). [1] [2] In women, melanomas most commonly occur on the legs; while in men, on the back. [2]

2024年2月17日 · Melanoma is a malignancy derived from the malignant transformation of melanocytes. Melanocytes are derived from the neural crest. Therefore, melanomas, although they arise from the skin, can develop in other locations where neural crest cells migrate, such as the gastrointestinal tract and brain.

Melanoma is a type of cancer that originates from the uncontrolled growth of melanocytes. While it can occur in various parts of the body, including the mucosal surfaces, uveal tract, and leptomeninges, this review will concentrate on cutaneous melanoma.

2 天之前 · Researchers have developed a new method to grow T cells that have greater longevity and can more efficiently destroy cancer cells in mouse models of melanoma compared to those grown in traditional ...

2019年12月1日 · Melanoma cells with stem cell-like traits, particularly located at the margin of the tumor (i.e., melanoma initiating cells), express and secrete in the microenvironment several factors associated with angiogenesis.

2018年5月14日 · Malignant transformation can result in melanoma cells that resemble different stages of their embryonic development. Our gene expression analysis of human melanoma cell lines and patient tumors revealed that melanoma follows a two-dimensional differentiation trajectory that can be subclassified into four progressive subtypes.

2024年5月16日 · Recent advances in immunotherapies underline the vital role of the tumor microenvironment (TME) during tumor progression. 17, 18 Multi-omic analyses have revealed diverse molecular subsets of melanoma, including cutaneous melanoma (CM) and uveal melanoma (UM), which correspond to different TME subtypes and exhibit distinct responses to ...